PHF21A antibody
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Name
PHF21A antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab06386
Tested Applications
ELISA, WB
Description
Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | PHD finger protein 21A (PHF21A) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 75 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q96BD5 |
| Gene ID | 51317 |
| Alias | BHC80, BM-006, IDDBCS, NEDMS,BHC80a |
| Background | Antibody anti-PHF21A |
| Status | RUO |
| Note | Mol. Weight 75 kDa |
Background
PHF21A is a PHD finger-containing protein involved in chromatin remodeling and transcriptional repression through its interactions with histone modifications. It is a component of the BHC complex, where it facilitates histone deacetylation and demethylation to suppress gene expression. PHF21A plays an essential role in neural development, where it regulates genes involved in neuronal differentiation, synaptic plasticity, and brain formation. It binds to unmethylated CpG islands and recruits chromatin modifiers to maintain gene silencing in a tissue-specific manner. Dysregulation or mutations in PHF21A are associated with neurodevelopmental disorders, including intellectual disability and Potocki-Shaffer syndrome, which manifest as craniofacial abnormalities and cognitive impairments. Knockout studies reveal disrupted neuronal differentiation, altered gene silencing, and developmental defects, highlighting its role in transcriptional repression, neurodevelopment, and chromatin regulation.
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