anti- PHF2 antibody

Background

PHF2 is a histone demethylase that specifically targets H3K9me2 to activate transcription by removing repressive methyl marks on histones. It serves as a transcriptional co-activator that regulates gene expression in response to metabolic and cellular stress signals. PHF2 is recruited to gene promoters through interactions with transcription factors and chromatin-associated proteins, promoting the activation of genes involved in lipid metabolism, gluconeogenesis, and inflammatory responses. It is expressed in metabolic tissues such as the liver, skeletal muscle, and adipose tissue, where it plays a role in energy homeostasis and inflammation control. Dysregulation of PHF2 is associated with metabolic diseases, including obesity, diabetes, and cancer, where its role in histone demethylation is disrupted. Knockdown studies reveal decreased transcriptional activation, impaired lipid metabolism, and abnormal inflammatory responses, highlighting its role in epigenetic regulation, metabolism, and cellular stress adaptation.