JADE1 antibody
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935106861
info@markelab.com
name
JADE1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab06382
tested applications
ELISA, WB
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | PHD finger protein 17 (JADE1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 58-61 kDa ,94-96 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q6IE81 |
| Alias | KIAA1807,PHF17,PHD finger protein 17 |
| Background | Antibody anti-JADE1 |
| Status | RUO |
| Note | Mol. Weight 58-61 kDa, 94-96 kDa |
JADE1 is a key chromatin-associated protein involved in histone acetylation and transcriptional regulation as part of the HBO1 histone acetyltransferase complex. Through its PHD finger domain, JADE1 recognizes acetylated histone H4 and facilitates H3/H4 acetylation, regulating chromatin accessibility during transcription, DNA replication, and repair. JADE1 is highly expressed in tissues undergoing rapid cell division, such as embryonic and epithelial tissues, where it controls cell cycle progression and differentiation. It is also involved in the Wnt/β-catenin signaling pathway, where it promotes the stabilization of β-catenin, influencing gene expression programs critical for development and tissue regeneration. Dysregulation of JADE1 is associated with cancer progression, fibrosis, and developmental disorders due to altered chromatin modification and transcriptional regulation. Knockdown studies demonstrate defects in histone acetylation, impaired cell cycle control, and disrupted transcriptional activation, highlighting its essential role in maintaining chromatin structure, epigenetic regulation, and cellular homeostasis.
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