anti- PHF11 antibody
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935106861
info@markelab.com
name
anti- PHF11 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab06378
tested applications
ELISA, WB, IHC, IF
Description
This gene encodes a protein containing a PHD (plant homeodomain) type zinc finger. This gene has been identified in some studies as a candidate gene for asthma. Naturally-occurring readthrough transcription may occur from the upstream SETDB2 (SET domain bifurcated 2) gene to this locus. Alternative splicing results in multiple transcript variants.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | PHD finger protein 11 |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 34 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9UIL8 |
| Gene ID | 51131 |
| Alias | PHF11,BCAP,NY-REN-34,IGER,BRCA1 C-Terminus-Associated Protein,Renal Carcinoma Antigen NY-REN-34,NYREN34,IGHER,IGEL,APY |
| Background | Antibody anti-PHF11 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
PHF11 is a PHD domain-containing protein involved in transcriptional regulation and immune responses. It interacts with transcription factors and chromatin modifiers to regulate the expression of genes associated with inflammation, immune cell activation, and DNA repair. PHF11 plays a key role in enhancing transcriptional activity at specific genomic loci, particularly in B cells and T cells, where it regulates immune responses, including cytokine production and class-switch recombination. It is highly expressed in lymphoid tissues, supporting its role in adaptive immunity and lymphocyte function. Dysregulation of PHF11 is associated with autoimmune diseases, inflammatory disorders, and cancer, where altered transcriptional regulation disrupts immune balance and cell proliferation. Knockout studies demonstrate impaired immune responses, reduced antibody production, and defective lymphocyte activation, highlighting its importance in transcriptional regulation, immune system maintenance, and adaptive immunity.
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