EGLN3 antibody
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935106861
info@markelab.com
name
EGLN3 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab06377
tested applications
ELISA, WB, IHC, IP
Description
EGLN3, also named as HPH-1, HIF-PH3, HPH-3 and PHD3, is a cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor(HIF) alpha proteins. It hydroxylates a specific proline found in each of the oxygen-dependent degradation(ODD) domains(N-terminal, NODD, and C-terminal, CODD) of HIF1A. It is a regulator of cardiomyocyte and neuronal apoptosis. EGLN3 can be a prognostic marker for gastric cancer.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | egl nine homolog 3 (EGLN3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 28kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9H6Z9 |
| Alias | Prolyl hydroxylase EGLN3,Egl nine homolog 3,HPH-1,Hypoxia-inducible factor prolyl hydroxylase 3 (HIF-PH3, HIF-prolyl hydroxylase 3, HPH-3),Prolyl hydroxylase domain-containing protein 3 (PHD3),EGLN3 |
| Background | Antibody anti-EGLN3 |
| Status | RUO |
| Note | Mol. Weight 28 kDa |
Descripción
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EGLN3, also named as HPH-1, HIF-PH3, HPH-3 and PHD3, is a cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor(HIF) alpha proteins. It hydroxylates a specific proline found in each of the oxygen-dependent degradation(ODD) domains(N-terminal, NODD, and C-terminal, CODD) of HIF1A. It is a regulator of cardiomyocyte and neuronal apoptosis. EGLN3 can be a prognostic marker for gastric cancer.
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