PEG10 antibody
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Description
Prevents apoptosis in hepatocellular carcinoma(HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation(By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein(MBP) promoter(By similarity).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | paternally expressed 10 (PEG10) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 50 kDa,100 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q86TG7 |
| Gene ID | 23089 |
| Alias | Retrotransposon-derived protein PEG10,Embryonal carcinoma differentiation-regulated protein,Mammalian retrotransposon-derived protein 2,Myelin expression factor 3-like protein 1 (MEF3-like protein 1),Paternally expressed gene 10 protein,Retrotransposon gag domain-containing protein 3,Retrotransposon-derived gag-like polyprotein,Ty3/Gypsy-like protein,PEG10,EDR,KIAA1051e,MAR2,MART2,MEF3L1,RGAG3 |
| Background | Antibody anti-PEG10 |
| Status | RUO |
| Note | Mol. Weight 50 kDa, 100 kDa |
Descripción
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PEG10 antibody
Prevents apoptosis in hepatocellular carcinoma(HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation(By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein(MBP) promoter(By similarity).
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Retrotransposon-Derived Protein PEG10 (PEG10) Antibody
PEG10 Antibody is a Rabbit Polyclonal antibody against PEG10. This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons. The longer isoform is the result of -1 translational frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2. It contains the active-site consensus sequence of the protease domain of pol proteins. Additional isoforms resulting from alternatively spliced transcript variants, as well as from use of upstream non-AUG (CUG) start codon, have been reported for this gene. Increased expression of this gene is associated with hepatocellular carcinomas.
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