CD274 antibody

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935106861
info@markelab.com
name
CD274 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab06281
tested applications
ELISA, WB, IHC,IF
Description
Programmed cell death ligand 1(CD274, or B7-H1, PD-L1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa, the apparent molecular weight has been reported as 45-70 kDa, suggesting probable glycosylation(PMID: 18760278; 16493058).?
Documents del producto
Product specifications
Category | Primary Antibodies |
Immunogen Target | CD274 molecule (CD274) |
Host | Mouse |
Reactivity | Human, Mouse, Pig |
Recommended Dilution | WB: 1:500-1:5000; IHC: 1:100-1:500; IF: 1:50-1:500 |
Clonality | monoclonal |
Conjugation | Unconjugated |
Isotype | IgG1 |
Clone ID | 6C11 |
Purity | ≥95% as determined by SDS-PAGE |
Purification | Protein A+G purification |
Size 1 | 100µg |
Form | liquid |
Tested Applications | ELISA, WB, IHC,IF |
Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
UniProt ID | Q9NZQ7 |
Alias | B7-H,B7H1,PDL,PD-L1,hPD-L1,PDCD1L1,PDCD1LG1,B7 homolog 1,PDCD1 ligand 1,Programmed death ligand 1,Programmed cell death 1 ligand 1 |
Background | Antibody anti-CD274 |
Status | RUO |
Note | Mol. Weight 40-50 kDa |
Descripción
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