CD274 antibody

Este producto es parte de CD274 molecule
Product Graph
Contáctenos para saber el precio

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
CD274 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab06281
tested applications
ELISA, WB, IHC,IF

Description

Programmed cell death ligand 1(CD274, or B7-H1, PD-L1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa, the apparent molecular weight has been reported as 45-70 kDa, suggesting probable glycosylation(PMID: 18760278; 16493058).?

Documents del producto

Instrucciones
Descargar
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
CD274 molecule (CD274)
Host
Mouse
Reactivity
Human, Mouse, Pig
Recommended Dilution
WB: 1:500-1:5000; IHC: 1:100-1:500; IF: 1:50-1:500
Clonality
monoclonal
Conjugation
Unconjugated
Isotype
IgG1
Clone ID
6C11
Purity
≥95% as determined by SDS-PAGE
Purification
Protein A+G purification
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IHC,IF
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
Q9NZQ7
Alias
B7-H,B7H1,PDL,PD-L1,hPD-L1,PDCD1L1,PDCD1LG1,B7 homolog 1,PDCD1 ligand 1,Programmed death ligand 1,Programmed cell death 1 ligand 1
Background
Antibody anti-CD274
Status
RUO
Note
Mol. Weight 40-50 kDa

Descripción

Related Products

APC-30030

APC Anti-Mouse CD274(10F.9G2)

Ver Producto
APC-30044

APC Anti-Human CD274(29E.2A3)

Ver Producto
EM0399

Mouse CD274 (Programmed cell death 1 ligand 1) ELISA Kit

Ver Producto