PAX3 antibody
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Name
PAX3 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab06170
Tested Applications
ELISA, IHC, WB
Description
Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | paired box 3 (PAX3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 60 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P23760 |
| Gene ID | 5077 |
| Alias | CDHS,HUP2,PAX-3,WS1,WS3 |
| Background | Antibody anti-PAX3 |
| Status | RUO |
| Note | Mol. Weight 60 kDa |
Background
PAX3 is a transcription factor belonging to the paired box (PAX) family, essential for embryonic development, particularly in neural crest cell migration, muscle formation, and melanocyte differentiation. PAX3 regulates genes involved in cell survival, proliferation, and lineage determination during development of the neural tube, skeletal muscles, and craniofacial structures. Mutations in PAX3 are associated with Waardenburg syndrome types I and III, characterized by hearing loss, pigmentation abnormalities, and skeletal defects due to impaired neural crest development. PAX3 also plays a role in myogenesis by activating MyoD and other myogenic regulatory factors. In cancers like alveolar rhabdomyosarcoma, chromosomal translocations involving PAX3 result in oncogenic fusion proteins (e.g., PAX3-FOXO1) that drive tumorigenesis by promoting unchecked proliferation and inhibiting differentiation. Knockout models show defects in neural crest migration, craniofacial anomalies, and muscle development failures, emphasizing PAX3's role in embryonic tissue patterning and organogenesis.
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