PARN antibody
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935106861
info@markelab.com
name
PARN antibody
category
Primary Antibodies
provider
FineTest
reference
FNab06150
tested applications
ELISA, WB, IHC
Description
The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | poly(A)-specific ribonuclease (deadenylation nuclease) (PARN) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:1000 - 1:3000; IHC: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 90 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O95453 |
| Gene ID | 5073 |
| Alias | Poly(A)-specific ribonuclease PARN,Deadenylating nuclease,Deadenylation nuclease,Polyadenylate-specific ribonuclease,PARN,DAN |
| Background | Antibody anti-PARN |
| Status | RUO |
| Note | Mol. Weight 90 kDa |
Descripción
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PARN antibody
The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Ver Producto