PABPC1 antibody

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935106861
info@markelab.com
name
PABPC1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab06096
tested applications
ELISA, WB, IHC, IF, FC, IP

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
poly(A) binding protein, cytoplasmic 1 (PABPC1)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
71 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IHC, IF, FC, IP
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
P11940
Gene ID
26986
Alias
Polyadenylate-binding protein 1 (PABP-1, Poly(A)-binding protein 1),PABPC1,PAB1,PABP,PABP1,PABPC2
Background
Antibody anti-PABPC1
Status
RUO
Note
Mol. Weight 71 kDa

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PABPC1 binds the poly (A) tail of mRNA. It may be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. PABPC1 can probably bind to cytoplasmic RNA sequences other than poly (A) in vivo. It may be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.

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