OSBPL3 antibody
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Description
Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum(ER) membranes(PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments(PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1(ITGB1) activation at the cell surface(PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology(PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion(PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3(PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol(PubMed:17428193).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | oxysterol binding protein-like 3 (OSBPL3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 101 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9H4L5 |
| Gene ID | 26031 |
| Alias | Oxysterol-binding protein-related protein 3 (ORP-3, OSBP-related protein 3),OSBPL3,KIAA0704,ORP3,OSBP3 |
| Background | Antibody anti-OSBPL3 |
| Status | RUO |
| Note | Mol. Weight 101 kDa |
Descripción
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OSBPL3 antibody
Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum(ER) membranes(PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments(PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1(ITGB1) activation at the cell surface(PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology(PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion(PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3(PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol(PubMed:17428193).
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Oxysterol Binding Protein Like 3 (OSBPL3) Antibody
OSBPL3 Antibody is a Rabbit Polyclonal antibody against OSBPL3. This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. The encoded protein is involved in the regulation of cell adhesion and organization of the actin cytoskeleton. Alternative splicing results in multiple transcript variants.
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