OSBP antibody
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Description
Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate(PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum(PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol(PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly(PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability(PubMed:18450749).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | oxysterol binding protein (OSBP) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 89 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P22059 |
| Gene ID | 5007 |
| Alias | Oxysterol-binding protein 1,OSBP,OSBP1 |
| Background | Antibody anti-OSBP |
| Status | RUO |
| Note | Mol. Weight 89 kDa |
Descripción
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OSBP antibody
Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate(PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum(PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol(PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly(PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability(PubMed:18450749).
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