NUP62 antibody
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Name
NUP62 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab05927
Tested Applications
ELISA, WB, IHC
Description
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | nucleoporin 62kDa (NUP62) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:1000 - 1:2000; IHC: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 65 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P37198 |
| Gene ID | 23636 |
| Alias | p62,IBSN,SNDI,nuclear pore glycoprotein p62,Nucleoporin Nup62 |
| Background | Antibody anti-NUP62 |
| Status | RUO |
| Note | Mol. Weight 65 kDa |
Background
Nucleoporin 62 (NUP62) is an essential member of the nuclear pore complex, playing a pivotal role in the selective transport of macromolecules across the nuclear envelope It facilitates the movement of RNA, proteins, and other molecules between the nucleus and cytoplasm, contributing to essential processes such as transcription, DNA replication, and cell cycle regulation NUP62 works in tandem with other nucleoporins to form the nuclear pore, allowing for controlled molecular trafficking essential for maintaining cellular function It interacts with various transport factors to regulate the export of RNA and ribosomal subunits to the cytoplasm, a key step in protein synthesis Dysregulation of NUP62 has been linked to numerous diseases, including cancers, where disruptions in nucleocytoplasmic transport lead to mislocalization of critical regulatory proteins, contributing to uncontrolled cell growth and survival Additionally, NUP62 is involved in cellular stress responses and repair mechanisms, emphasizing its role in tissue homeostasis and cell survival under adverse conditions The importance of NUP62 in gene regulation, protein synthesis, and cellular stress management highlights its central role in maintaining proper cellular function and tissue integrity
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