anti- NR2E3 antibody

Este producto es parte de NR2E - nuclear receptor subfamily 2 group E member
anti- NR2E3 antibody

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935106861

info@markelab.com

Precio

Precio a consultar

Antibody anti-NR2E3

proveedor

FineTest

reference

FNab05842

Tested Applications

ELISA, WB, IHC, IF, FC

reactivity

human,mouse,rat

status

RUO

clonality

polyclonal

Descripción

Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod-and cone-specific genes, including rhodopsin, M-and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M-and S-cone opsin expression.


Background

Nuclear receptor subfamily 2 group E member 3 (NR2E3), also known as photoreceptor-specific nuclear receptor, is a nuclear receptor involved in the regulation of retinal development and the function of photoreceptors in the eye NR2E3 is specifically expressed in the retina, where it regulates the differentiation of photoreceptor cells, including rods and cones It plays a critical role in the development of the retina by influencing the expression of genes involved in the differentiation and maintenance of photoreceptors, which are essential for vision NR2E3 also controls the transcriptional network that governs the survival of retinal cells and the response to light Inherited mutations in NR2E3 are associated with retinal degenerative diseases, such as retinitis pigmentosa, which leads to progressive vision loss by impairing photoreceptor function In addition, NR2E3’s role in regulating the development of other retinal cell types and maintaining visual function makes it an important factor in ocular health and a potential target for therapeutic interventions in retinal diseases

Características del producto

category

Primary Antibodies


clonality

polyclonal


reactivity

human,mouse,rat


immunogen target

nuclear receptor subfamily 2, group E, member 3


host

Rabbit


isotype

IgG


conjugation

Unconjugated


form

liquid


tested applications

ELISA, WB, IHC, IF, FC


observerd MW

43-45 kDa


purity

≥95% as determined by SDS-PAGE


purification

Immunogen affinity purified


recommended dilution

WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:100


size 1

100µg


storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)


or code

NR2E3


alias

PNR,RNR,rd7,ESCS,RP37,Retina-specific nuclear receptor,Photoreceptor-specific nuclear receptor


note

This product is for research use only.


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