NGEF antibody
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935106861
info@markelab.com
name
NGEF antibody
category
Primary Antibodies
provider
FineTest
reference
FNab05720
tested applications
ELISA, WB, IP, IHC
Description
Acts as a guanine nucleotide exchange factor(GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1-and CDC42-stimulated growth cone extension(By similarity).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | neuronal guanine nucleotide exchange factor (NGEF) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:1000; IP: 1:500-1:1000; IHC: 1:50-1:500 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 75 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IP, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8N5V2 |
| Gene ID | 25791 |
| Alias | Ephexin-1,Eph-interacting exchange protein,Neuronal guanine nucleotide exchange factor,NGEF |
| Background | Antibody anti-NGEF |
| Status | RUO |
| Note | Mol. Weight 75 kDa |
Descripción
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