NEIL3 antibody
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Description
DNA glycosylase which prefers single-stranded DNA(ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA(dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin(Sp) and guanidinohydantoin(Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | nei endonuclease VIII-like 3(E. coli) (NEIL3) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 62-68 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8TAT5 |
| Gene ID | 55247 |
| Alias | Endonuclease 8-like 3,DNA glycosylase FPG2,DNA glycosylase/AP lyase Neil3,Endonuclease VIII-like 3,Nei-like protein 3,NEIL3 |
| Background | Antibody anti-NEIL3 |
| Status | RUO |
| Note | Mol. Weight 62-68 kDa |
Descripción
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NEIL3 antibody
DNA glycosylase which prefers single-stranded DNA(ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA(dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin(Sp) and guanidinohydantoin(Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.
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