NEDD4 antibody
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Description
This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | neural precursor cell expressed, developmentally down-regulated 4 (NEDD4) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 120 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P46934 |
| Gene ID | 4734 |
| Alias | E3 ubiquitin-protein ligase NEDD4,Cell proliferation-inducing gene 53 protein,HECT-type E3 ubiquitin transferase NEDD4,Neural precursor cell expressed developmentally down-regulated protein 4 (NEDD-4),NEDD4,KIAA0093,NEDD4-1,RPF1 |
| Background | Antibody anti-NEDD4 |
| Status | RUO |
| Note | Mol. Weight 120 kDa |
Descripción
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This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN.
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