NDC80 antibody

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Description
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity(PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore(PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules(PubMed:23085020).
Documents del producto
Product specifications
Category | Primary Antibodies |
Immunogen Target | NDC80 homolog, kinetochore complex component (NDC80) |
Host | Rabbit |
Reactivity | Human, Mouse, Rat |
Recommended Dilution | WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200 |
Clonality | polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Observed MW | 76 kDa |
Purity | ≥95% as determined by SDS-PAGE |
Purification | Immunogen affinity purified |
Size 1 | 100µg |
Form | liquid |
Tested Applications | ELISA, WB, IHC, IP |
Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
UniProt ID | O14777 |
Gene ID | 10403 |
Alias | Kinetochore protein NDC80 homolog,Highly expressed in cancer protein,Kinetochore protein Hec1 (HsHec1),Kinetochore-associated protein 2,Retinoblastoma-associated protein HEC,NDC80,HEC,HEC1,KNTC2 |
Background | Antibody anti-NDC80 |
Status | RUO |
Note | Mol. Weight 76 kDa |
Descripción
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