SLC8A1 antibody
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | solute carrier family 8(sodium/calcium exchanger), member 1 (SLC8A1) |
| Host | Rabbit |
| Reactivity | Human, Rat, Mouse |
| Recommended Dilution | WB: 1:500 - 1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 120 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P32418 |
| Gene ID | 6546 |
| Alias | Sodium/calcium exchanger 1,Na(+)/Ca(2+)-exchange protein 1,Solute carrier family 8 member 1,SLC8A1,CNC,NCX1 |
| Background | Antibody anti-SLC8A1 |
| Status | RUO |
| Note | Mol. Weight 120 kDa |
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In cardiac myocytes, Ca (2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca (2+) centration during contraction is primarily due to release of Ca (2+) from intracellular stores. However, some Ca (2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca (2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca (2+) that entered across the sarcolemma must be extruded from the cell. The Na (+) Ca (2+) exchanger is the primary mechanism by which the Ca (2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.
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