MYO7B antibody
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Description
Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. May link the complex to the actin core bundle of microvilli(Probable).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | myosin VIIB (MYO7B) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q6PIF6 |
| Gene ID | 4648 |
| Alias | Unconventional myosin-VIIb |
| Background | Antibody anti-MYO7B |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
Myosin VIIB (MYO7B) is a motor protein from the myosin family, which is involved in ATP-dependent cellular movements Myosin VIIB, like other myosins, moves along actin filaments, converting chemical energy into mechanical work This motor protein is crucial for cellular processes such as vesicular transport, endocytosis, and cell migration MYO7B plays a specific role in the auditory and visual systems, where it is involved in the function of sensory cells, including the hair cells of the inner ear and photoreceptors in the retina In the inner ear, MYO7B helps maintain the structure and function of hair cells, which are responsible for detecting sound vibrations and balancing signals Disruption in MYO7B function leads to hearing loss and progressive blindness, as seen in Usher syndrome type 2, where both deafness and vision impairment occur due to defects in inner ear and retinal cells
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