MYO1A antibody
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Description
Involved in directing the movement of organelles along actin filaments.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | myosin IA (MYO1A) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 130 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IF, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9UBC5 |
| Gene ID | 4640 |
| Alias | Unconventional myosin-Ia,Brush border myosin I (BBM-I, BBMI),Myosin I heavy chain (MIHC),MYO1A,MYHL |
| Background | Antibody anti-MYO1A |
| Status | RUO |
| Note | Mol. Weight 130 kDa |
Descripción
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Myosin IA (MYO1A) Antibody
MYO1A belongs to the myosin superfamily. Myosins are molecular motors that, upon interaction with actin filaments, utilize energy from ATP hydrolysis to generate mechanical force. Each myosin has a conserved N-terminal motor domain that contains both ATP-binding and actin-binding sequences. Following the motor domain is a light-chain-binding 'neck' region containing 1-6 copies of a repeat element, the IQ motif, that serves as a binding site for calmodulin or other members of the EF-hand superfamily of calcium-binding proteins. At the C-terminus, each myosin class has a distinct tail domain that serves in dimerization, membrane binding, protein binding, and/or enzymatic activities and targets each myosin to its particular subcellular location. The kidney epithelial cell line, LLC-PK1-CL4 (CL4), forms a well ordered brush border (BB) on its apical surface. Experiments indicate that the brush border population of the protein turns over rapidly, while its head and tail domains interact transiently with the core actin and plasma membrane, respectively. A rapidly exchanging pool of the protein envelops an actin core bundle that, by comparison, is static in structure.
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Human Myosin IA (MYO1A) Protein
Recombinant Myosin IA (MYO1A) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
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