anti- MYLK2 antibody
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935106861
info@markelab.com
name
anti- MYLK2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab05494
tested applications
ELISA, WB
Description
Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | myosin light chain kinase 2 |
| Host | Rabbit |
| Reactivity | human |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 65kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9H1R3 |
| Gene ID | 85366 |
| Alias | KMLC,MLCK,MLCK2,skMLCK,Myosin light chain kinase 2, skeletal cardiac muscle |
| Background | Antibody anti-MYLK2 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
Myosin light chain kinase 2 (MYLK2) is a muscle-specific isoform of myosin light chain kinase predominantly expressed in skeletal muscle tissue. MYLK2 plays a key role in regulating myosin activity during muscle contraction by phosphorylating the regulatory light chains of myosin II, a process critical for force generation and sarcomere function. The kinase activity of MYLK2 is tightly regulated by calcium-calmodulin signaling, ensuring precise control of contractile responses during dynamic skeletal muscle activities such as exercise and locomotion. MYLK2 also contributes to the adaptive remodeling of muscle fibers in response to mechanical stress and physiological demands. Mutations or dysregulation of MYLK2 have been associated with myopathies and muscle weakness, emphasizing its essential role in maintaining muscular integrity and function.
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