Anti-Mullerian Hormone Receptor Type 2 (AMHR2) Antibody
357.5€ (100 µg)
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Name
Anti-Mullerian Hormone Receptor Type 2 (AMHR2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx037274
Tested Applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the AMHR2 protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Anti-Mullerian Hormone Receptor Type 2 (AMHR2) Immunogen: Recombinant fragment corresponding to 207-440 AA of human AMHR2. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 63 kDa |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | AMHR2,AMHR,MISR2 |
| Background | Antibody anti-AMHR2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
The anti-Müllerian hormone type-2 receptor (AMHR2) is a transmembrane serine/threonine kinase receptor crucial in reproductive system development and function. AMHR2 is expressed primarily in the gonads, particularly in Sertoli cells in males and granulosa cells in females, where it mediates the effects of anti-Müllerian hormone (AMH). During male embryogenesis, AMHR2 plays a pivotal role in the regression of the Müllerian ducts, structures that would otherwise develop into female reproductive organs, ensuring proper male reproductive tract formation. In females, AMHR2 is involved in ovarian folliculogenesis, regulating the sensitivity of granulosa cells to FSH (follicle-stimulating hormone), and is considered a marker of ovarian reserve. Mutations in the AMHR2 gene have been associated with disorders of sexual development, such as persistent Müllerian duct syndrome (PMDS) in males. AMHR2 also holds therapeutic potential as a target in the treatment of ovarian cancer, where its expression is often aberrantly regulated, and in fertility assessment due to its role in ovarian function. Its role in reproductive biology underscores its importance in both clinical and developmental contexts.
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