Anti-Mullerian Hormone Receptor Type 2 (AMHR2) Antibody
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Description
The AMH receptor (AMHR or AMHR2) is a serine/threonine kinase with a single transmembrane domain belonging to the family of type II receptors for TGF-beta-related proteins. Anti-Mullerian hormone (AMH) and its receptor are involved in the regression of Mullerian ducts in male fetuses. Male sex differentiation is mediated by 2 discrete hormones produced by the fetal testis. Testosterone, produced by Leydig cells, virilizes the external genitalia and promotes prostatic growth; anti-Mullerian hormone (AMH) results in regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Anti-Mullerian Hormone Receptor Type 2 (AMHR2) Immunogen: KLH-conjugated synthetic peptide between 65-91 amino acids from the N-terminal region of human AMHR2. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/500. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 62.8 kDa |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q16671 |
| Alias | AMHR2,AMHR,MISR2 |
| Background | Antibody anti-AMHR2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
The anti-Müllerian hormone type-2 receptor (AMHR2) is a transmembrane serine/threonine kinase receptor crucial in reproductive system development and function. AMHR2 is expressed primarily in the gonads, particularly in Sertoli cells in males and granulosa cells in females, where it mediates the effects of anti-Müllerian hormone (AMH). During male embryogenesis, AMHR2 plays a pivotal role in the regression of the Müllerian ducts, structures that would otherwise develop into female reproductive organs, ensuring proper male reproductive tract formation. In females, AMHR2 is involved in ovarian folliculogenesis, regulating the sensitivity of granulosa cells to FSH (follicle-stimulating hormone), and is considered a marker of ovarian reserve. Mutations in the AMHR2 gene have been associated with disorders of sexual development, such as persistent Müllerian duct syndrome (PMDS) in males. AMHR2 also holds therapeutic potential as a target in the treatment of ovarian cancer, where its expression is often aberrantly regulated, and in fertility assessment due to its role in ovarian function. Its role in reproductive biology underscores its importance in both clinical and developmental contexts.
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Anti-Mullerian Hormone Receptor Type 2 (AMHR2) Antibody
The AMH receptor (AMHR or AMHR2) is a serine/threonine kinase with a single transmembrane domain belonging to the family of type II receptors for TGF-beta-related proteins. Anti-Mullerian hormone (AMH) and its receptor are involved in the regression of Mullerian ducts in male fetuses. Male sex differentiation is mediated by 2 discrete hormones produced by the fetal testis. Testosterone, produced by Leydig cells, virilizes the external genitalia and promotes prostatic growth; anti-Mullerian hormone (AMH) results in regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes.
Ver Producto
Anti-Mullerian Hormone Receptor Type 2 (AMHR2) Antibody
The AMH receptor (AMHR or AMHR2) is a serine/threonine kinase with a single transmembrane domain belonging to the family of type II receptors for TGF-beta-related proteins. Anti-Mullerian hormone (AMH) and its receptor are involved in the regression of Mullerian ducts in male fetuses. Male sex differentiation is mediated by 2 discrete hormones produced by the fetal testis. Testosterone, produced by Leydig cells, virilizes the external genitalia and promotes prostatic growth; anti-Mullerian hormone (AMH) results in regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes.
Ver Producto
Anti-Mullerian Hormone Receptor Type 2 (AMHR2) Antibody
The AMH receptor (AMHR or AMHR2) is a serine/threonine kinase with a single transmembrane domain belonging to the family of type II receptors for TGF-beta-related proteins. Anti-Mullerian hormone (AMH) and its receptor are involved in the regression of Mullerian ducts in male fetuses. Male sex differentiation is mediated by 2 discrete hormones produced by the fetal testis. Testosterone, produced by Leydig cells, virilizes the external genitalia and promotes prostatic growth; anti-Mullerian hormone (AMH) results in regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes.
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