MTA2 antibody
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Description
May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | metastasis associated 1 family, member 2 (MTA2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 75 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O94776 |
| Gene ID | 9219 |
| Alias | Metastasis-associated protein MTA2,Metastasis-associated 1-like 1 (MTA1-L1 protein),p53 target protein in deacetylase complex,MTA2,MTA1L1,PID |
| Background | Antibody anti-MTA2 |
| Status | RUO |
| Note | Mol. Weight 75 kDa |
Descripción
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MTA2 antibody
May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.
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May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.
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Metastasis-Associated Protein MTA2 (MTA2) Antibody
MTA2 Antibody is a Rabbit Polyclonal antibody against MTA2. This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.
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