MSH3 antibody
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Description
Component of the post-replicative DNA mismatch repair system(MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops(IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | mutS homolog 3 (MSH3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 123 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P20585 |
| Gene ID | 4437 |
| Alias | DNA mismatch repair protein Msh3 (hMSH3),Divergent upstream protein (DUP),Mismatch repair protein 1 (MRP1),MSH3,DUC1,DUG |
| Background | Antibody anti-MSH3 |
| Status | RUO |
| Note | Mol. Weight 123 kDa |
Descripción
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