MGP antibody
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Description
Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | matrix Gla protein (MGP) |
| Host | Mouse |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:5000; IHC: 1:500-1:1500 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Clone ID | 8C3 |
| Observed MW | 13 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Protein A+G purification |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P08493 |
| Gene ID | 4256 |
| Alias | Matrix Gla protein (MGP),Cell growth-inhibiting gene 36 protein,MGP,MGLAP |
| Background | Antibody anti-MGP |
| Status | RUO |
| Note | Mol. Weight 13 kDa |
Descripción
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MGP antibody
This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia.
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Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
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