MEN1 antibody
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Description
Essential component of a MLL/SET1 histone methyltransferase(HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3(H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression(By similarity). May be involved in DNA repair.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | multiple endocrine neoplasia I (MEN1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 63-70 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O00255 |
| Gene ID | 4221 |
| Alias | Menin,MEN1,SCG2 |
| Background | Antibody anti-MEN1 |
| Status | RUO |
| Note | Mol. Weight 63-70 kDa |
Descripción
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