MAP2K3 antibody

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935106861
info@markelab.com
name
MAP2K3 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab05114
tested applications
ELISA, WB, IHC, IF

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
mitogen-activated protein kinase kinase 3 (MAP2K3)
Host
Rabbit
Reactivity
Human
Recommended Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:100
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
37-40 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IHC, IF
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
P46734
Gene ID
5606
Alias
Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3, MAPKK 3),MAPK/ERK kinase 3 (MEK 3),Stress-activated protein kinase kinase 2 (SAPK kinase 2, SAPKK-2, SAPKK2),MAP2K3,MEK3,MKK3,PRKMK3,SKK2
Background
Antibody anti-MAP2K3
Status
RUO
Note
Mol. Weight 37-40 kDa

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MAP2K3 (pS189) Antibody is a Rabbit Polyclonal antibody against MAP2K3 (pS189). MKK3 and MKK6 are two closely related dual-specificity protein kinases that activate p38 MAP kinase. MKK3 and MKK6 both phosphorylate and activate p38 MAP kinase at its activation site, Thr-Gly-Tyr, but do not phosphorylate or activate Erk1/2 or SAPK/JNK. Phosphorylation of p38 MAP kinase dramatically stimulates its ability to phosphorylate protein substrates such as ATF-2 and Elk-1. MKK3 and MKK6 are both activated by different forms of cellular stress and inflammatory cytokines. Activation of MKK3 and MKK6 occurs through phosphorylation of Ser189 and Thr193 on MKK3 and Ser207 and Thr211 on MKK6.

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