MDM2 antibody
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935106861
info@markelab.com
name
MDM2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab05077
tested applications
ELISA, IHC, WB, IF
Description
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Mdm2 p53 binding protein homolog ( Mouse ) (MDM2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 50 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, WB, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q00987 |
| Gene ID | 4193 |
| Alias | E3 ubiquitin-protein ligase Mdm2,Double minute 2 protein (Hdm2),Oncoprotein Mdm2,RING-type E3 ubiquitin transferase Mdm2,p53-binding protein Mdm2,MDM2 |
| Background | Antibody anti-MDM2 |
| Status | RUO |
| Note | Mol. Weight 50 kDa |
Descripción
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Human MDM2 (E3 ubiquitin-protein ligase Mdm2) ELISA Kit
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MDM2 antibody
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Ver Producto