MBNL3 antibody
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Description
Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T(TNNT2) pre-mRNA exon inclusion but induces insulin receptor(IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology(DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | muscleblind-like 3(Drosophila) (MBNL3) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 38 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9NUK0 |
| Gene ID | 55796 |
| Alias | Muscleblind-like protein 3,Cys3His CCG1-required protein,Muscleblind-like X-linked protein,Protein HCHCR,MBNL3,CHCR,MBLX39,MBXL |
| Background | Antibody anti-MBNL3 |
| Status | RUO |
| Note | Mol. Weight 38 kDa |
Descripción
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