MAS1 antibody
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Description
This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Proto-oncogene Mas (MAS1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:50-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 41 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P04201 |
| Alias | MAS1,MAS,angiotensin 1-7 receptor ,MAS1 proto-oncogene G protein-coupled receptor,MAS1 proto-oncogene, MasR, Mgra |
| Background | Antibody anti-MAS1 |
| Status | RUO |
| Note | Mol. Weight 41 kDa |
Descripción
MAS1 is a gene that encodes a G protein-coupled receptor (GPCR) involved in various physiological processes, including cardiovascular regulation, neuronal signaling, and cellular proliferation. It was originally identified as a proto-oncogene due to its potential role in tumorigenesis. MAS1 is involved in signaling pathways that regulate the growth and differentiation of cells. It is also known for its interaction with the angiotensin peptide, particularly in the regulation of blood pressure and fluid balance. MAS1 functions in mediating the effects of angiotensin peptides on vascular smooth muscle and endothelial cells, contributing to vasodilation and regulating blood pressure. Studies suggest that MAS1 may play a protective role in cardiovascular health by modulating angiotensin-induced vasoconstriction. Dysregulation of MAS1 signaling has been implicated in various cancers and cardiovascular diseases, and research into its role as a tumor suppressor or oncogene could provide novel insights for therapeutic strategies.
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MAS1 antibody
This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7).
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