MAML1 antibody
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935106861
info@markelab.com
name
MAML1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab04960
tested applications
ELISA, WB
Description
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | mastermind-like 1(Drosophila) (MAML1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 108-120kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q92585 |
| Gene ID | 9794 |
| Alias | Mastermind-like protein 1 (Mam-1),MAML1,KIAA0200 |
| Background | Antibody anti-MAML1 |
| Status | RUO |
| Note | Mol. Weight 108-120 kDa |
Descripción
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