anti- LRRC4C antibody
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935106861
info@markelab.com
name
anti- LRRC4C antibody
category
Primary Antibodies
provider
FineTest
reference
FNab04859
tested applications
ELISA, WB, IHC
Description
May promote neurite outgrowth of developing thalamic neurons.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | leucine rich repeat containing 4C |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:500-1:1000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 72 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9HCJ2 |
| Gene ID | 57689 |
| Alias | LRRC4C, KIAA1580, NGL1,Netrin-G1 ligand ,NGL-1 |
| Background | Antibody anti-LRRC4C |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
LRRC4C, or netrin-G ligand 4 (NGL-4), is a member of the leucine-rich repeat protein family involved in synaptic adhesion, axon guidance, and neural circuit formation. It binds to netrin-G proteins at synaptic junctions, facilitating the establishment and stabilization of excitatory synapses in the central nervous system. LRRC4C is highly expressed in the brain, particularly in regions responsible for cognitive and motor functions, where it regulates synaptic plasticity, neuronal migration, and dendritic spine development. Dysregulation of LRRC4C has been linked to neurodevelopmental disorders, such as autism spectrum disorders (ASD) and epilepsy, where disrupted synaptic organization and connectivity lead to impaired brain function. Knockout studies reveal defects in synaptic architecture, altered neuronal communication, and reduced cognitive performance, highlighting its critical role in synaptic development, neural circuit organization, and proper brain function.
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