anti- LRRC4C antibody
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935106861
info@markelab.com
name
anti- LRRC4C antibody
category
Primary Antibodies
provider
FineTest
reference
FNab04859
tested applications
ELISA, WB, IHC
Descripción del producto
May promote neurite outgrowth of developing thalamic neurons.
Documents del producto
Instrucciones
Data sheet
Especificaciones del producto
| Alias | LRRC4C, KIAA1580, NGL1,Netrin-G1 ligand ,NGL-1 |
| Background | Antibody anti-LRRC4C |
| Category | Primary Antibodies |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Form | liquid |
| Gene ID | 57689 |
| Host | Rabbit |
| Immunogen Target | leucine rich repeat containing 4C |
| Isotype | IgG |
| Name | anti- LRRC4C antibody |
| Note | This product is for research use only. |
| Observed MW | 72 kDa |
| Provider | FineTest |
| Purification | Immunogen affinity purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:500-1:1000; IHC: 1:20-1:200 |
| Reference | FNab04859 |
| Size 1 | 100µg |
| Status | RUO |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Tested Applications | ELISA, WB, IHC |
| UniProt ID | Q9HCJ2 |
Descripcion del producto en español
Background en español
LRRC4C, or netrin-G ligand 4 (NGL-4), is a member of the leucine-rich repeat protein family involved in synaptic adhesion, axon guidance, and neural circuit formation. It binds to netrin-G proteins at synaptic junctions, facilitating the establishment and stabilization of excitatory synapses in the central nervous system. LRRC4C is highly expressed in the brain, particularly in regions responsible for cognitive and motor functions, where it regulates synaptic plasticity, neuronal migration, and dendritic spine development. Dysregulation of LRRC4C has been linked to neurodevelopmental disorders, such as autism spectrum disorders (ASD) and epilepsy, where disrupted synaptic organization and connectivity lead to impaired brain function. Knockout studies reveal defects in synaptic architecture, altered neuronal communication, and reduced cognitive performance, highlighting its critical role in synaptic development, neural circuit organization, and proper brain function.
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