anti- LRRC41 antibody
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935106861
info@markelab.com
name
anti- LRRC41 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab04857
tested applications
ELISA, IHC, WB
Description
Probable substrate recognition component of an ECS(Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | leucine rich repeat containing 41 |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 80-90 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q15345 |
| Gene ID | 10489 |
| Alias | LRRC41, MUF1, PP7759 |
| Background | Antibody anti-LRRC41 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
LRRC41 is a protein with proposed roles in DNA damage repair and ubiquitin-mediated proteolysis studies suggest it functions as an E3 ubiquitin ligase interacting with other proteins involved in the ubiquitin-proteasome system to regulate protein turnover and cellular stress responses LRRC41 is widely expressed in tissues undergoing high cellular turnover and is particularly enriched in hematopoietic cells where it may influence cell cycle progression and apoptosis its involvement in DNA repair pathways highlights its potential role in maintaining genomic stability and preventing tumorigenesis mutations or altered expression of LRRC41 have been associated with certain cancers and hematological disorders ongoing research is exploring its function in protein quality control and its potential as a therapeutic target in diseases associated with proteostasis and genomic instability further studies are needed to define its exact biological mechanisms and regulatory networks
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