LRP2-Specific antibody
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935106861
info@markelab.com
name
LRP2-Specific antibody
category
Primary Antibodies
provider
FineTest
reference
FNab04847
tested applications
ELISA, WB, IHC
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | low density lipoprotein-related protein 2 (LRP2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:200-1:1000; IHC: 1:100-1:400 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 280 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P98164 |
| Alias | Low-density lipoprotein receptor-related protein 2,DBS,GP330,LRP-2,Megalin |
| Background | Antibody anti-LRP2 |
| Status | RUO |
| Note | Mol. Weight 280 kDa |
Low-Density Lipoprotein Receptor-Related Protein 2 (LRP2), also known as megalin, is a large endocytic receptor primarily known for its role in cellular uptake of a wide variety of ligands. LRP2 belongs to the LDL receptor family and is highly expressed in epithelial cells, particularly in the proximal tubule cells of the kidneys, the choroid plexus of the brain, and the inner ear. By binding and internalizing various ligands, including lipoproteins, vitamins, hormones, and protein complexes, LRP2 is essential for nutrient reabsorption, hormonal balance, and cellular signaling. LRP2’s functions are particularly significant in the kidneys, where it reabsorbs essential proteins and other molecules from the filtrate to prevent loss through urine. In the brain, it has roles in neurodevelopment and modulates responses to growth factors. LRP2’s complex functionality extends to embryonic development, where it influences morphogen signaling pathways critical to organ formation. Given its roles in various physiological systems, LRP2’s dysfunction or deficiency has been linked to developmental disorders, kidney disease, and metabolic syndromes.
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