LNX1 antibody
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Description
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65(By similarity). Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ligand of numb-protein X 1 (LNX1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 70 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8TBB1 |
| Gene ID | 84708 |
| Alias | E3 ubiquitin-protein ligase LNX,Ligand of Numb-protein X 1,Numb-binding protein 1,PDZ domain-containing RING finger protein 2,RING-type E3 ubiquitin transferase LNX,LNX1,LNX,PDZRN2 |
| Background | Antibody anti-LNX1 |
| Status | RUO |
| Note | Mol. Weight 70 kDa |
Descripción
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