anti- LILRB4 antibody
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Description
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Leukocyte immunoglobulin-like receptor subfamily B member 4 |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 49 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8NHJ6 |
| Alias | Leukocyte immunoglobulin-like receptor subfamily B member 4,B4,ILT3,LIR5,CD85K,ILT-3,LIR-5,Immunoglobulin-like transcript 3,Leukocyte immunoglobulin-like receptor 5,Monocyte inhibitory receptor HM18 |
| Background | Antibody anti-LILRB4 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
Leukocyte Immunoglobulin-Like Receptor B4 (LILRB4), also known as CD85K, ILT3, or LIR-5, is an inhibitory receptor expressed mainly on myeloid cells, such as dendritic cells, macrophages, and monocytes. As a member of the leukocyte immunoglobulin-like receptor (LILR) family, it functions primarily to suppress immune responses, maintaining immune homeostasis and preventing overactivation. LILRB4’s immune-modulatory role is particularly crucial in preventing autoimmune reactions and regulating inflammatory responses. Its expression is primarily restricted to cells of the myeloid lineage, making it a key component in myeloid cell function. The gene encoding LILRB4 is located within a cluster of LILR genes on chromosome 19q13.4, close to other LILR genes, which are involved in immune modulation.
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