LILRA4 antibody

Este producto es parte de LILRA4 - leukocyte immunoglobulin like receptor A4
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935106861
info@markelab.com
name
LILRA4 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab04776
tested applications
ELISA, WB

Description

May act as receptor for class I MHC antigens. Ligand binding leads to the activation of eosinophils and to the release of RNASE2, IL4 and leukotriene C4.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
leukocyte immunoglobulin-like receptor, subfamily A(with TM domain), member 4 (LILRA4)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
WB: 1:500-1:2000
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
48kd
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
P59901
Gene ID
23547
Alias
Leukocyte immunoglobulin-like receptor subfamily A member 4,ILT7,CD85g,Immunoglobulin-like transcript 7
Background
Antibody anti-LILRA4
Status
RUO
Note
Mol. Weight 48 kDa

Descripción

LILRA4 (Leukocyte Immunoglobulin-Like Receptor A4), also known as ILT7 or CD85g, is a member of the leukocyte immunoglobulin-like receptor (LILR) family, which is primarily involved in modulating immune responses. This receptor family is part of the Leukocyte Receptor Complex (LRC) on chromosome 19q13.4, where several LILR family members are located, often associated with immune regulation. LILRA4 is distinct among LILRs as it is uniquely expressed on plasmacytoid dendritic cells (pDCs), a specialized dendritic cell subset primarily responsible for antiviral responses and producing type I interferons in response to viral infection. LILRA4 plays a suppressive role on pDCs by modulating interferon production, impacting immune responses, and helping maintain immune homeostasis. The regulation of interferon responses by LILRA4 is crucial, particularly because excessive interferon production can contribute to inflammatory and autoimmune disorders

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