LEPR antibody

Este producto es parte de LEPR - leptin receptor
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935106861
info@markelab.com
name
LEPR antibody
category
Primary Antibodies
provider
FineTest
reference
FNab04751
tested applications
ELISA, IHC, IF, WB

Description

LEPR plays an important role in the regulation of glucose homeostasis via feeding and adiposity. Alternatively spliced transcript variants encoding different isoforms of LEPR have been described. This antibody can recognize long (LEPRb) and short (LEPRa,c,d) isoforms.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
leptin receptor (LEPR)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:10-1:100
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
150 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, IHC, IF, WB
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
P48357
Gene ID
3953
Alias
OBR,OB-R,CD295,LEP-R,LEPRD,HuB219,OB receptor
Background
Antibody anti-LEPR
Status
RUO
Note
Mol. Weight 150 kDa

Descripción

The leptin receptor (LEPR) is a cell surface receptor that plays a central role in energy homeostasis, metabolism, and body weight regulation. LEPR is the receptor for leptin, a hormone primarily secreted by adipose (fat) tissue that signals satiety and energy sufficiency to the brain. Leptin and its receptor are fundamental to regulating food intake, body weight, and energy expenditure. When leptin binds to LEPR, it triggers a cascade of intracellular signals that inform the central nervous system about the body's energy reserves, particularly in the hypothalamus, which then influences appetite suppression, metabolism, and other endocrine functions. LEPR is essential in maintaining homeostatic control over body mass, as dysregulation or mutations in the leptin receptor pathway can lead to obesity, diabetes, and metabolic syndrome.

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