KDM5C antibody
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Description
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2(By similarity).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | lysine(K)-specific demethylase 5C (KDM5C) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 171-180 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P41229 |
| Gene ID | 8242 |
| Alias | Lysine-specific demethylase 5C,Histone demethylase JARID1C,Jumonji/ARID domain-containing protein 1C,Protein SmcX,Protein Xe169,[histone H3]-trimethyl-L-lysine(4) demethylase 5C,KDM5C,DXS1272E,JARID1C,SMCX,XE169 |
| Background | Antibody anti-KDM5C |
| Status | RUO |
| Note | Mol. Weight 171-180 kDa |
Descripción
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