KDM6B antibody

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Documents del producto
Product specifications
Category | Primary Antibodies |
Immunogen Target | jumonji domain containing 3, histone lysine demethylase (KDM6B) |
Host | Rabbit |
Reactivity | Human, Mouse |
Recommended Dilution | WB: 1:500-1:2000 |
Clonality | polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Observed MW | 180 kDa |
Purity | ≥95% as determined by SDS-PAGE |
Purification | Immunogen affinity purified |
Size 1 | 100µg |
Form | liquid |
Tested Applications | ELISA, WB |
Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
UniProt ID | O15054 |
Alias | Lysine-specific demethylase 6B,JmjC domain-containing protein 3,Jumonji domain-containing protein 3,Lysine demethylase 6B,[histone H3]-trimethyl-L-lysine(27) demethylase 6B,KDM6B,JMJD3,KIAA0346 |
Background | Antibody anti-KDM6B |
Status | RUO |
Note | Mol. Weight 180 kDa |
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Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe (II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
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