INSIG2 antibody
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935106861
info@markelab.com
name
INSIG2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab04334
tested applications
ELISA, WB, IHC, IF
Description
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins(SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | insulin induced gene 2 (INSIG2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 30 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9Y5U4 |
| Gene ID | 51141 |
| Alias | Insulin-induced gene 2 protein (INSIG-2),INSIG2 |
| Background | Antibody anti-INSIG2 |
| Status | RUO |
| Note | Mol. Weight 30 kDa |
Descripción
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