IL2RB antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | interleukin 2 receptor, beta (IL2RB) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 70-75kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P14784 |
| Gene ID | 3560 |
| Alias | CD122,IMD63,IL15RB,P70-75,High affinity IL-2 receptor subunit beta,Interleukin-15 receptor subunit beta |
| Background | Antibody anti-IL2RB |
| Status | RUO |
| Note | Mol. Weight 70-75 kDa |
Descripción
IL2RB, or interleukin-2 receptor beta subunit, is a crucial component of the interleukin-2 (IL-2) receptor complex. The IL-2 receptor is vital for T cell activation, proliferation, and survival and is central to immune responses. IL2RB, specifically, is essential for transmitting signals that control the growth, differentiation, and survival of T cells. The IL-2 receptor complex consists of three subunits: the IL-2 receptor alpha (IL2RA or CD25), IL-2 receptor beta (IL2RB or CD122), and IL-2 receptor gamma (IL2RG or CD132). Together, these subunits form a high-affinity receptor for IL-2 that is primarily expressed on activated T cells, natural killer (NK) cells, and other immune cell types. IL2RB, encoded by the IL2RB gene on chromosome 22q12.3, is a key signaling subunit. It binds IL-2 with intermediate affinity independently but, when combined with IL2RG, forms the high-affinity IL-2 receptor that effectively transmits intracellular signals upon IL-2 binding. IL2RB plays a significant role in immune homeostasis and regulation, influencing T cell differentiation, NK cell development, and peripheral tolerance. Dysregulation of IL2RB expression or function is linked to various immune disorders, including autoimmune diseases, immunodeficiencies, and certain cancers.
Related Products
Interleukin 2 Receptor Beta (IL2RB) Antibody
IL2RB Antibody is a Rabbit Polyclonal antibody against IL2RB. The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.
Ver Producto
Human Interleukin 2 Receptor Beta (IL2RB) CLIA Kit
Human Interleukin 2 Receptor Beta (IL-2Rb) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Interleukin 2 Receptor Beta (IL-2Rb).
Ver Producto
Interleukin 2 Receptor Beta (IL2RB) Antibody
IL2RB Antibody is a Rabbit Polyclonal against IL2RB.
Ver Producto