IL20 antibody
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935106861
info@markelab.com
name
IL20 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab04248
tested applications
ELISA, WB, IHC, IF
Description
The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | interleukin 20 (IL20) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:100; IF: 1:50 - 1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 20 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9NYY1 |
| Gene ID | 50604 |
| Alias | IL-20,IL10D,ZCYTO10,Cytokine Zcyto10 |
| Background | Antibody anti-IL20 |
| Status | RUO |
| Note | Mol. Weight 20 kDa |
Descripción
Interleukin 20 (IL20) is a member of the IL-10 cytokine family, which includes structurally related cytokines like IL-19, IL-22, IL-24, and IL-26. These cytokines share common biological functions in regulating immune responses, inflammation, and tissue homeostasis. IL-20, in particular, is predominantly associated with the modulation of skin, lung, and other epithelial tissues, where it exerts its effects on inflammation, tissue repair, and the innate immune response. IL-20 is produced by various cell types, including monocytes, keratinocytes, endothelial cells, and fibroblasts. Its expression is induced by pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α, particularly in tissues experiencing inflammation or injury. IL-20 acts primarily on epithelial and immune cells to regulate tissue homeostasis and inflammation, making it an important mediator in diseases like psoriasis, rheumatoid arthritis, and pulmonary inflammation.
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