IL36RN antibody
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Name
IL36RN antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab04238
Tested Applications
ELISA, WB
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | interleukin 1 family, member 5(delta) (IL36RN) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1:1000-1:4000 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | 2B8 |
| Observed MW | 42 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Protein A+G purification |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9UBH0 |
| Alias | IL-36Ra,IL-1F5,FIL1, FIL1Delta,IL1F5 |
| Background | Antibody anti-IL36RN |
| Status | RUO |
| Note | Mol. Weight 42 kDa |
Background
IL36RN, also known as IL-36Ra, is an anti-inflammatory cytokine that functions as a natural inhibitor of IL-36 signaling. It binds to the IL-36 receptor (IL1RL2) and prevents its activation by IL36A, IL36B, and IL36G, thereby blocking downstream NF-κB, MAPK, and JNK signaling pathways. IL36RN is primarily expressed in keratinocytes, epithelial cells, and immune cells, where it regulates inflammation and prevents excessive immune activation at epithelial barriers. It plays a key role in maintaining tissue homeostasis and limiting pathological inflammation in conditions such as psoriasis, where mutations in IL36RN lead to uncontrolled IL-36 activity, severe inflammation, and pustular psoriasis. IL36RN is also implicated in mucosal immunity and inflammatory diseases of the skin, lungs, and gastrointestinal tract. Knockout studies reveal heightened IL-36 signaling, excessive cytokine production, and severe tissue inflammation, underscoring IL36RN's role as a key anti-inflammatory regulator and protective factor in immune homeostasis and barrier tissue health.
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