IL13RA2 antibody
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Name
IL13RA2 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab04221
Tested Applications
ELISA, WB, IHC
Description
Binds as a monomer with high affinity to interleukin-13(IL13), but not to interleukin-4(IL4).
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | interleukin 13 receptor, alpha 2 (IL13RA2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 50-65 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q14627 |
| Gene ID | 3598 |
| Alias | IL-13 receptor subunit alpha-2,CT19,IL-13R,IL13BP,CD213A2,Interleukin-13-binding protein |
| Background | Antibody anti-IL13RA2 |
| Status | RUO |
| Note | Mol. Weight 50-65 kDa |
Background
Interleukin-13 receptor subunit alpha-2 (IL13RA2) is a protein encoded by the IL13RA2 gene, which functions as part of the immune system’s response to inflammation and certain immune-regulatory mechanisms. IL13RA2 is closely related to interleukin-13 receptor subunit alpha-1 (IL13RA1), both of which bind to the cytokine interleukin-13 (IL-13). However, IL13RA2 is distinctive in that it acts as a “decoy” receptor, binding IL-13 with high affinity but not actively initiating intracellular signaling, thereby modulating the effects of IL-13 on immune responses. IL13RA2 has roles in regulating allergic reactions and fibrotic processes and is often upregulated in various pathological conditions, including certain cancers. The protein's interactions with IL-13 have implications for tissue remodeling, fibrosis, and immune regulation, making it an important target in the fields of immunology, oncology, and fibrosis research.
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