IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2(PTGS2/COX-2), as well as enhance the production of nitric oxide(NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.
The Interleukin 17 family is a group of pro-inflammatory cystine knot cytokines primarily produced by T helper 17 cells in response to stimulation with IL-23. IL17A, was previously known in rodents as CTLA8. In humans, The IL-17 family includes IL17A (sometimes referred to as "IL-17"), IL17B, IL17C, IL17D, IL17E (also known as IL-25), and IL17F. One of the most prominent roles of IL-17 is its participation in initiating and mediating proinflammatory responses. IL-17 is commonly associated with allergic reactions and can induce the production of various other cytokines (such as IL-6, G-CSF, GM-CSF, IL-1β, TGF-β, TNF-α), chemokines (including IL-8, GRO-α, and MCP-1), and prostaglandins (e.g., PGE2) from different cell types, including fibroblasts, endothelial cells, epithelial cells, keratinocytes, and macrophages
La familia interleucina 17 es un grupo de citocinas proinflamatorias del nudo de cistina ( 3 S_S ), producidas principalmente por células T Helper 17 en respuesta a la estimulación con IL-23. IL17A, se conocía anteriormente en roedores como CTLA8. En humanos, la familia IL-17 incluye IL17A (a veces denominada "IL-17"), IL17B, IL17C, IL17D, IL17E (también conocida como IL-25) e IL17F. Una de las funciones más destacadas de la IL-17 es su participación en el inicio y la mediación de respuestas proinflamatorias. La IL-17 se asocia comúnmente con reacciones alérgicas y puede inducir la producción de otras citoquinas (como IL-6, G-CSF, GM-CSF, IL-1β, TGF-β, TNF-α), quimiocinas (incluida IL -8, GRO-α y MCP-1) y prostaglandinas (p. ej., PGE2) de diferentes tipos de células, incluidos fibroblastos, células endoteliales, células epiteliales, queratinocitos y macrófagos.
Primary Antibodies
monoclonal
human
interleukin 17A
Mouse
IgG1
Unconjugated
liquid
ELISA, WB, FC
18 kDa
≥95% as determined by SDS-PAGE
Protein A+G purification
WB: 1:500-1:1000
100µg
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
IL17A
IL17,CTLA8,IL-1,ILA17,CTLA-8,IL-17A
This product is for research use only.
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