Human Interleukin 17A (IL17A) Protein
234€ (5 µg)
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935106861
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name
Human Interleukin 17A (IL17A) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx261640
tested applications
SDS-PAGE
Description
Interleukin 17A (IL17A) Protein is a recombinant cytokine.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Interleukin 17A (IL17A) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: 31 kDa Sequence Fragment: 264 amino acids (2 chains of 132aa). |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Purification | Proprietary Chromatographic Techniques. |
| Size 1 | 5 µg |
| Size 2 | 25 µg |
| Size 3 | 1 mg |
| Form | Lyophilized It is recommended to reconstitute the lyophilized Interleukin 17 in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
| Tested Applications | SDS-PAGE |
| Buffer | 20mM Citrate, 0.1M NaCl, pH4.5. |
| Availability | Shipped within 5-10 working days. |
| Storage | Lyophilized Interleukin 17A although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL17 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q16552 |
| Alias | IL17,CTLA8,IL-1,ILA17,CTLA-8,IL-17A |
| Background | Protein IL17A |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
IL17A is a pro-inflammatory cytokine produced primarily by T-helper 17 (Th17) cells and other immune cells in response to infection and tissue damage IL17A plays a central role in innate and adaptive immunity by stimulating the production of chemokines, cytokines, and antimicrobial peptides that recruit neutrophils and enhance host defense against bacterial and fungal infections Dysregulated IL17A production is associated with autoimmune diseases such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease, where it contributes to chronic inflammation and tissue damage IL17A also plays a role in cancer, where it can promote tumor growth and metastasis by inducing angiogenesis, immune suppression, and chronic inflammation IL17A-targeted therapies, including monoclonal antibodies such as secukinumab, have been developed to treat autoimmune and inflammatory conditions by neutralizing IL17A activity and reducing inflammation
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