IL10 antibody
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935106861
info@markelab.com
name
IL10 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab04212
tested applications
ELISA, WB,IHC
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | interleukin 10 (IL10) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1:2000-1:20000; IHC: 1:20-1:500 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | 2D3 |
| Observed MW | 21 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Protein A+G purification |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB,IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P22301 |
| Alias | CSIF,GVHDS,IL-10,IL10A,TGIF,Cytokine synthesis inhibitory factor |
| Background | Antibody anti-IL10 |
| Status | RUO |
| Note | Mol. Weight 21 kDa |
IL10 is an anti-inflammatory cytokine produced by macrophages, T regulatory cells, and other immune cells to suppress excessive immune responses and maintain tissue homeostasis IL10 signaling occurs through the IL-10 receptor (IL10R) and activates the JAK/STAT3 pathway, inhibiting the production of pro-inflammatory cytokines such as TNF-α, IL1β, and IL6 It plays a pivotal role in immune tolerance, limiting damage caused by chronic inflammation and infections Dysregulation of IL10 expression is associated with autoimmune diseases, such as Crohn's disease, multiple sclerosis, and psoriasis IL10 also exerts immunosuppressive effects in the tumor microenvironment, facilitating tumor progression and immune evasion due to its inhibitory influence on T cells and antigen-presenting cells IL10-based therapies are being explored for managing inflammatory diseases and promoting immune modulation in cancer and chronic infections
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